Repressing mutant proteins
نویسندگان
چکیده
منابع مشابه
Generation of Helper Plasmids Encoding Mutant Adeno-associated Virus Type 2 Capsid Proteins with Increased Resistance against Proteasomal Degradation
Objective(s): Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast and simple method is presented to generate AAV2 vector helper plasmids encod...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2019
ISSN: 1471-003X,1471-0048
DOI: 10.1038/s41583-019-0211-8